Cervical cancer. Conclusion

Posted on December 18th, 2009 by Canadian Health in Cervical cancer

I’d like to talk at this point about the three different grades. Grade 1 squamous cell carcinoma; grade 2 squamous cell carcinoma; and Grade 3 squamous cell carcinoma. How do we grade them? Basically, grade 1, or well-differentiated squamous cell carcinomas, look very similar to the normal squamous epithelium; they have keratin pearls, they have intercellular bridges and they look like squamous epithelium. The poorly-differentiated, or grade 3, squamous cell carcinomas really don’t have many features of squamous epithelium and one has to look to see if this is a squamous cell carcinoma or adenocarcinoma . This is the difference between a well-differentiated and poorly-differentiated carcinoma. Again, the grading system has conflicting studies as to whether this portends diagnosis and it appears most likely that the stage is obviously the most important prognostic factor.
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At this point, I would also like to talk about the variety of squamous cell carcinomas. There are actually six types. The first one which is very important for you to remember is the microinvasive squamous cell carcinoma of the cervix. This is basically defined as a tumor which invades the stroma less than 3 mm below the base of the epithelium and which has no lymphatic or vascular space invasion. If one keeps strict criteria, these tumors actually do not metastasize and do not recur, if they keep to the criteria of less than 3 mm and no vascular or lymphatic invasion.

The second type, obviously the most common, is an invasive squamous cell carcinoma. The third one is what is known as a verrucous carcinoma . Verrucous carcinoma actually has a very good prognosis; it recurs, but not metastasize. The fourth one is called a warty carcinoma. The warty carcinomas have marked HPV-like effects but also have malignant cytology. This has a prognosis in between the invasive squamous cell carcinomas and verrucous carcinomas. Transitional cell carcinomas are extremely rare; they look like transitional epithelium. They are similar prognostically to the invasive squamous cell carcinomas but they may have late recurrences. Lastly is the lymphoepithelioma-like carcinoma, which is a carcinoma which is associated with a strong lymphocytic response. While you don’t have to know the difference between the different types histologically, some of them have a little different prognosis.
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I’ve shown you a case of adenocarcinoma of the cervix, squamous cell carcinoma of the cervix and we have talked about the different subtypes. There are other epithelial tumors of the cervix – there is adenocystic, adenoid basal, glassy cell and a lot of histologic subtypes. One of the subtypes I’d like to mention is a tumor that can be mistaken or confused with a poorly-differentiated squamous cell carcinoma. It is quite important to distinguish the two because this is an extremely aggressive tumor. These tumors are very cellular, they have sheets of cells, they do not have any gland formation and the cells are small with scant cytoplasm. They have sort-of stippled chromatin and numerous mitotic figures. Small cell carcinoma of the cervix is another subtype worth mentioning. If one does neuroendocrine markers or immunohistochemistry, these are actually neuroendocrine positive. Neuroendocrine tumors are like oat cell carcinoma of the lung. Again, they can be confused with poorly-differentiated squamous cell carcinoma, especially the more small cell type. They are extremely aggressive. These patients present with a barrel-shaped cervix. They are very infiltrative tumors. Clinically, although uncommon, they may have ectopic ACTH production.

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