Endometrioid adenocarcinomas
The second most common is the endometrioid adenocarcinomas and those look very similar to the endometrial adenocarcinomas. Those comprise about thirty percent of cases.
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The third most common is the clear cell adenocarcinomas, which are strongly associated with DES exposure. They are seen in young women who have had previous in utero exposure to DES. However, people who have not been exposed to DES can also develop clear cell adenocarcinoma. The cytoplasm is clear because it contains glycogen as opposed to mucin.
Minimal deviation adenocarcinomas are so-called because they actually lack the cytologic features of malignancy. They look cytologically extremely benign; however, they infiltrate the stroma way below the normal level of the endocervical glands. They infiltrate beyond 7 mm. They are very difficult to pick up. One really needs a deep biopsy to pick them up. They are strongly associated with Peutz-Jeghers syndrome. In addition, if there is an adenocarcinoma that is going to be associated with an ovarian carcinoma, this is the adenocarcinoma which is often associated with ovarian adenocarcinoma. Ovarian adenocarcinomas tend to be a mucinous type or the six-core tumor type with annular tubules. Minimal deviation adenocarcinomas are very rare.
The fifth serous subtype is serous adenocarcinoma, similar to the endometrioid; these are rare, but you may see it in the cervix.
The mesonephric adenocarcinomas are derived from the mesonephric remnants which are basically seen in the lateral wall of the cervix.
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