Archive for August, 2008.

Screening for colorectal cancer

Posted on August 18th, 2008 by Canadian Health in Cancer Treatment, Cancer screening

Colorectal cancer. Screening for colorectal cancer is recommended for everyone over the age of 50. Fecal occult blood testing is the major test. It should be done on an annual basis. The best way to do this is not by doing a digital rectal examination and then smearing the stool on a card. It is best done by sending the patient home with three stool hem occult cards and having them mailed back to your office. That’s so there are three different specimens done where the patient is on a special diet prior to doing the test. This is one of the places where the American Cancer Society beat out the Preventative Health Services task force. The ACS has been saying for years and years and years, that all patients should have flexible sigmoidoscopies starting at the age of 50, every two to three years. U.S. Preventive Health Services task force said, no, there’s no data to support that, until their most recent edition where, based on a very good case controlled study which showed a decreased risk of dying from colorectal cancer if a patient had undergone flexible sigmoidoscopy. The recommendation is now to do so. It is unclear what the interval should be. There are some who say between every three to five years. Some, Preventative Health Services task force leaves this unclear, but says perhaps once every ten years would be useful. And, by the way, the different … I don’t do flexible sigmoidoscopy, so I refer to gastroenterologists to do it and each one gives me back a slightly different recommendation on a normal exam, about when the next one should be done. Canadian viagra at Canadian health care.
Of course, if a person has fecal occult blood positive stool, colonoscopy is, I think, considered the community standard for the best follow-up test. Most of us would consider barium enema evaluation or flexible sigmoidoscopy after a known positive occult blood test, to be inadequate. There are some high risk groups. A first degree relative with colorectal cancer; it is unclear, still, if the increased risk of having a first degree relative justifies the use of colonoscopy over other screening methods. That increased risk, though, may justify beginning screening before the age of 50; and many of the members of my group, without data to support this, actually start recommending screening colonoscopy to patients after the age of 40 if there is a first degree relative. There is no data to support that, but at the moment, that is where we are as a community standard. We also believe that you need increased surveillance for patients with familial polyposis, ulcerative colitis, a previous history of known adenomatous polyps, or previous history of colon cancer. If you are watching the literature, it’s also unclear that once you do a … if you do a screening colonoscopy, when should the next one occur. And that is changing from every three to every five, to perhaps every ten years.
Cervical cancer. Regular pap tests are recommended for all women who are sexually active. There is little evidence that annual screening is better than every three year testing. But this is assuming that you are sitting with a patient who is at standard risk, and these are risk factors that do not make you standard risk. So early onset of sexual intercourse, multiple sex partners. One question is to get an agreement as to what does multiple mean. Cialis professional – erectile dysfunction treatment. Is that two, is that three, is that four, is that five partners? Or is it more likely to be the case where you have one partner who has multiple partners, which might be a more significant risk problem. Low socioeconomic status. HIV infection; the recommendation is still every six month pap smears in patients with HIV disease. This is because it is known that human papilloma virus, which is the virus that is known to probably induce cervical cancer, seems to grow faster in patients who are HIV positive. Of course, if there is a previous history of abnormal pap smear, that patient should have ongoing annual exams. The thing we like to argue about is what about patients above the age of 65? Should they be undergoing pap smear screening and how often? By the way, the American College of Obstetrics and Gynecology says, “Yes they should be getting them on an annual basis.” There is no data to support that.
The other question is, what about the indication for pap testing in women who have undergone hysterectomy? There is a recent article in the Journal of American Medical Association looking at a large number of women who had undergone total hysterectomy, meaning that their cervix had been removed along with the uterus, which is the standard procedure now. And it’s been shown that basically if you are doing it, what you are really screening for is vaginal cancer. You are no longer screening for cervical cancer. Vaginal cancer is extraordinarily rare. Random pap smear scrapings of the vaginal mucosa are probably useless for making that diagnosis. So based on data, there’s no reason to do it. By the way, in my group, there’s no data but what we do is if a woman has had all normal pap smears consistently before the age of 65, we would sort of drop down to once every 3-5 years screening women past the age of 65. But if you happen to see, which I still do, every now and then you see a patient who is not … I see her at 67 for her hypertension and then find out that she hasn’t had a pap smear for about 20 years or since the birth of her last child, that patient, I believe in more intensive screening for a few years.

Screening for Cancer

Posted on August 6th, 2008 by Canadian Health in Cancer screening

If a woman has a previous history of breast cancer or carcinoma in situ, she is at higher risk. Or if she has had a breast biopsy and was known to have atypical hyperplasia. There are associations with breast cancer; exposure to high dose radiation, late age at first pregnancy, if you haven’t had children, or whatever this means, high socioeconomic status. Women who drink more than one or two drinks per day may also be at slightly higher risk for breast cancer. If the woman is healthy and she drinks more than two drinks a day, that’s a reason to do more intensive breast cancer screening. Female viagra online.
What’s the sensitivity of mammography? It’s 10-15% lower – the overall sensitivity is 75-88% – it’s lower in women age 40-49. The specificity ranges from 98.5 – 83%. Radiologists would say that they use much better radiographic equipment and that they would claim that their sensitivity and specificity rates are much better than these published numbers. The adverse effects of screening is that the false positive rate in women between 40 and 49 is 7-10%. There is also a false positive rate of 4.5 – 8% in women from 50-59, and that rate drops as you rise in age, as breast tissue becomes less and less dense. One of the costs that you need to consider, and what feels like I spend more time doing in my practice, is the increased anxiety that women experience when they require a biopsy.
Routine screening is recommended every one to two years with mammography, for women ages 50-69. For women between 40 and 49, there is conflicting evidence regarding the clinical benefit from mammography. There has only been one trial that really tested well, whether this was effective in women between 40 and 49. The big problem is they don’t show a survival benefit. The tumor biology in women who develop breast cancer before menopause is very different from the tumor biology of women who develop breast cancer when they are 70. In women who develop breast cancer premenopausally, breast cancer then is a more systemic disease. Whereas, in women who develop breast cancer late, it seems to be a more localized disease.
Cheap Nymphomax
There is a survival benefit to doing mammography between 40 and 49. It doesn’t seem to occur until 10 to 12 years after you begin the screening, but there is a survival benefit. It’s about an 18% survival benefit. However, when you start doing mammography between 50 and 60, the survival benefit is 22-25%, but it begins 4-5 years after you begin to do the screening. Survival benefit is 18% and it takes 10 years.
If all we do is make a science-driven decision, along with a cost-driven decision, we would probably not recommend screening women between 40 and 49. The NCI consensus panel said we should not be screening women; we should not recommend screening women between 40 and 49. Canadian pharmacy a lot of medications.
The reasons to screen are that the patient may have the preference. If a woman is at high risk for breast cancer, she should certainly begin mammogram screening. If I have a patient whose sister developed breast cancer at the age of 42, that patient is going to get screened on an annual basis in my practice.
The sensitivity of mammography might improve in the future. Studies are being done about whether MRI would be a better technique, but my sense is that the cost involved would not make it a cost-effective intervention. If the treatment of breast cancer makes this major leap, and it has been making major leaps, perhaps we will decide that the survival benefit would be worthwhile. I’ve said that you should be doing annual or biannual screening for women from 60 to 69. What about women higher than 75? Because actually this is where the majority of breast cancers are. There is a very high burden of disease, and if you expect that the patient has a survival of more than five years. You go ahead and recommend. There is not a strict recommendation for screening, but most practitioners would recommend screening. Within my own group, we believe in annual or biannual screening in all women above the age of 50.