Staging for Carcinoma of the Corpus Uteri
Stage IA G 1, 2, 3 Tumor limited to endometrium
Stage IB G 1, 2, 3 Invasion to less than one half of the myometrium
Stage IC G 1, 2, 3 Invasion to more than one half of the myometrium
Stage IIA G 1, 2, 3 Endocervical glandular involvement only
Stage IIB G 1, 2, 3 Cervical stromal invasion
Stage IIIA G 1, 2, 3 Tumor invades serosa and/or adnexa, and/or positive peritoneal cytology
Stage IIIB G 1, 2, 3 Vaginal metastases
Stage IIIC G 1, 2, 3 Metastases to pelvic and/or paraaortic lymph nodes
Stage IVAG 1, 2, 3 Tumor invasion of bladder and/or bowel mucosa
Stage IVB Distant metastases including intraabdominal and/or inguinal lymph nodes
Histopathology–Degree of Differentiation
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Cases of carcinoma of the corpus should be classified (or graded) according to the degree of
histologic differentiation as follows:
G1 = 5% or less of a nonsquamous or nonmorular solid growth pattern
G2 = 6-50% of a nonsquamous or nonmorular solid growth pattern
G3 = more than 50% of a nonsquamous or nonmorular solid growth pattern
Notes on Pathological Grading
1. Notable nuclear atypia, inappropriate for the architectural grade, raises the grade of a grade 1 or grade 2 tumor by 1.
2. In serous adenocarcinomas, clear-cell adenocarcinomas, and squamous cell carcinomas, nuclear grading takes precedence.
3. Adenocarcinomas with benign squamous differentiation are graded according to the nuclear grade of the glandular component.
Rules Related to Staging
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1. Because corpus cancer is now staged surgically, procedures previously used for determination of stages are no longer applicable, such as the findings from fractional dilation and curettage to differentiate between stage I and stage II.
2. It is appreciated that there may be a small number of patients with corpus cancer who will be treated primarily with radiation therapy. If that is the case, the clinical staging adopted by FIGO in 1971 would still apply, but designation of that staging system would be noted.
3. Ideally, width of the myometrium should be measured along with the width of tumor invasion.